@markkaplan20
I used to wonder why doctors fight so hard to defend LDL and ApoB. Then I understood. Imagine you are a cardiologist. You have spent 30 years prescribing statins. You have told thousands of patients their cholesterol is the problem. Your guidelines say it. Your training says it. Your colleagues say it. Now imagine a study proves it was never the main driver. What do you do with that? Dugani et al. JAMA Cardiology. 2021. 28,024 women. 21.4 years. 50+ biomarkers ranked by heart disease risk.